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How Cbd Keeps Thc In Check

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Many people who use cannabis do it for the euphoric effects caused by the main psychoactive ingredient, tetrahydrocannabinol, often called THC. But THC can also cause unpleasant side effects like paranoia, dissociative thoughts, impaired memory or even psychotic episodes. As cannabis has become more potent, it is becoming more likely that some users will experience those effects. But another compound present in the plant, the non-psychoactive cannabidiol, actually works against THC and can block those negative effects.

Now a team of researchers led by Steven Laviolette, a neuroscientist at the University of Western Ontario in London, Canada, has figured out how the two compounds interact in the brain, and how CBD, as cannabidiol is also known, balances out the negative psychiatric side effects of THC. Their work was published recently in the Journal of Neuroscience.

Working with rats, Laviolette focused on an area of the brain called the ventral hippocampus, which is involved in emotional control and is known to be vulnerable to some of the long-term effects of high-potency THC. Rats who were given THC exhibited many of the acute negative side effects in behavioral tests, such as anxiety about new environments, and problems with social interaction, memory, and their ability to filter out unnecessary sensory data. When they examined the rats’ brains after the tests, the researchers determined that the effects were caused by an overactive cellular signaling molecule called extracellular signal-regulated kinase, or ERK.

“We found that THC is overstimulating the ERK pathway, altering oscillation patterns in the brain linked to schizophrenia and disturbing the dopamine system,” said Laviolette.

Source: https://420intel.com/articles/2019/10/07/how-cbd-keeps-thc-check

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